Introduction :

Dolphin Pharmaceuticals is a leading Coseal (Surgical sealant) supplier from India, based in Surat, Gujarat, specializing in supply of high-quality specialty medicines. We serve pharmacy, distributors, hospitals, and healthcare organizations worldwide with quality-assured Coseal (Surgical sealant).

Coseal (Surgical sealant) is primarily used to seal tissue surfaces and reduce fluid leakage during certain surgical procedures under the supervision of qualified healthcare professionals. Dolphin Pharmaceuticals is committed to providing authentic medicines, competitive pricing, complete support, global healthcare requirements.

Coseal (Surgical sealant)

Coseal (Sealant) is a surgical sealant used to help seal tissue surfaces and reduce fluid leakage during certain surgical procedures. It belongs to the class of surgical sealants and haemostatic adjuncts, depending on its specific formulation and approved indication. Such sealants are used to support tissue sealing, help prevent leakage, and assist surgeons in achieving effective closure during surgery. The product is manufactured and marketed by Baxter India Pvt. Ltd.

Product Introduction

COSEAL Surgical Sealant is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.

COSEAL Surgical Sealant is designed to provide a rapid intraoperative seal at the suture line and to maintain this protection during the critical postoperative period.

This allows the body time to complete its natural wound healing process at the anastomosis, supporting the integrity of your work at vascular reconstruction sites that may be at risk for increased bleeding due to:

• Coagulopathies

• High pressure suture lines

• Friable vascular tissue

COSEAL Surgical Sealant is not to be used in place of sutures, staples, or mechanical closure. Do not inject COSEAL into vessels.

As a fully synthetic hydrogel, COSEAL Surgical Sealant is developed for the right balance of strength, elasticity and time-to-resorption, and is completely free of glutaraldehyde and bovine components.

BURST STRENGTH : Can withstand postoperative spikes over 5x normal systolic pressure at up to 660 [+/- 150] mm Hg (in vitro burst test for closure of puncture defects 0.6-0.9 mm diameter, n=4) in porcine carotid artery.

ELASTICITY : Thin, motion-responsive seal provides biomechanical compatibility and supports natural vascular dilation.

RESORPTION : Resorbed within 30 days of application. Remains at application site for up to 7 days.

COSEAL Surgical Sealant is easy to apply how and where you want.

• Translucent seal – Helps to keep suture lines visible

• Can be sutured through - After COSEAL Surgical Sealant has polymerized, additional sutures can be easily placed through it without disturbing the seal

• No refrigeration required - COSEAL Surgical Sealant can be stored at room temperature (approximately 25 ºC)

• Multiple application options – COSEAL Surgical Sealant may be used with a full range of spray systems for focal and broad application – Use caution when applying with pressurized gas

COSEAL Surgical Sealant Indication

COSEAL is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.

Important Risk Information for COSEAL

• COSEAL is not to be used in place of sutures, staples, or mechanical closure.

• COSEAL swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel resorbs. Therefore, surgeons should consider the maximum swell volume and its possible effect on surrounding anatomic structures potentially sensitive to compression.

• Apply only as a thin layer.

• Use caution when applying with pressurized gas.

• Do not place devices or other objects on top of tissue where COSEAL has been applied, until the material is fully polymerized (non-tacky).

• Do not apply COSEAL over any devices or objects that will need to be removed. COSEAL must not be used as a mechanism of adherence, even temporarily, for any object.

• Do not inject COSEAL into vessels.