Introduction of ESENTRA
120 INJECTION:

ESENTRA 120
INJECTION contains Denosumab which belongs to the group of medicines
called Monoclonal antibodies. It is used in adults to manage advanced cancer
and to manage serious complications caused by bone metastasis (Ex. fractures,
pressure on the spinal cord, radiation therapy, or surgery). It is also used to
manage giant cell tumours of the bone, which cannot be managed by surgery, especially
in adults whose bones have stopped growing. Symptoms include a visible mass and
bone joints being affected (fracture, fluid buildup, limited movement,
swelling, and pain in the joints).

Denosumab binds
to RANKL, a protein that is essential for the formation, function, and survival
of osteoclasts (the cells responsible for bone resorption). It inhibits
osteoclast formation, function, and survival, thereby decreasing bone
resorption and increasing bone mass and strength. Along with this management, your
doctor might ask you to make certain lifestyle changes, such as maintaining
good oral hygiene and quitting smoking. Your doctor may ask you to undergo a
dental examination before you start the management. ESENTRA 120 INJECTION is
not recommended for use in patients with hypocalcemia (low calcium levels in
the blood) and unhealed wounds from oral surgery. Before receiving ESENTRA 120
INJECTION, inform your doctor if you have any problems with your mouth or teeth
(poor dental health, gum disease, etc.).

ESENTRA 120
INJECTION is not recommended among women who are pregnant. Consult your doctor
for advice before receiving ESENTRA 120 INJECTION if you are breast-feeding.
ESENTRA 120 INJECTION is not recommended for children and adolescents under 18
years of age, except for adolescents with giant cell tumours of the bone whose
bones have stopped growing. The most common side effects of receiving ESENTRA
120 INJECTION are pain in the bones, joints, and muscles, shortness of breath,
diarrhea, hypophosphatemia (low phosphate level), and excessive sweating.

Uses of ESENTRA 120 INJECTION:

• Giant cell
  tumour of bone in adults whose bones have stopped growing
• Complications
  caused by bone metastasis in advanced cancer (fracture, pressure on the
  spinal cord)

How to use ESENTRA 120 INJECTION:

ESENTRA 120
INJECTION will usually be administered to you subcutaneously (under the skin)
by a doctor or nurse. You should also take calcium and vitamin D supplements
while being managed with ESENTRA 120 INJECTION. Your doctor will decide the
correct dose and duration for you depending on your age, body weight, and
disease condition.